Best 10 St John’s Wort and Valerian Supplements in 2025: Top Picks for Mood and Relaxation

Feeling overwhelmed by stress, anxiety, or sleepless nights? You’re not alone—millions are turning to natural remedies like St John’s Wort and Valerian to support mood and relaxation without the side effects of pharmaceuticals. These powerful herbs offer a holistic approach to emotional well-being and restful sleep. In this comprehensive guide, we’ve meticulously reviewed the best 10 St John’s Wort and Valerian supplements available on Amazon in 2025. Using customer reviews, expert insights, and rigorous analysis, we’ll help you choose the perfect product for your wellness journey. Trust our unbiased recommendations to make an informed decision.

What Are St John’s Wort and Valerian?

St John’s Wort (Hypericum perforatum) is a flowering plant renowned for its mood-enhancing properties, often used to alleviate symptoms of mild to moderate depression and anxiety. Its active compounds, like hypericin and hyperforin, boost serotonin, dopamine, and norepinephrine levels in the brain. Valerian (Valeriana officinalis), a root-based herb, is celebrated for its calming effects, promoting restful sleep and reducing anxiety by interacting with GABA receptors. Together, these herbs create a synergistic effect, addressing both emotional balance and relaxation. Always consult a healthcare provider before use, as St John’s Wort can interact with medications like antidepressants, and Valerian may cause drowsiness.

Why Choose a St John’s Wort and Valerian Supplement?

For those seeking natural alternatives to pharmaceuticals, St John’s Wort and Valerian supplements offer a gentle yet effective way to manage stress, mild mood disorders, and sleep issues. They’re ideal for adults experiencing occasional anxiety, low mood, or insomnia, particularly those preferring plant-based solutions. Key considerations include potency (standardized extracts like 0.3% hypericin), purity (Non-GMO, organic), dosage convenience, and brand reliability. These supplements are not a cure-all but can be a valuable tool for emotional and mental wellness when chosen wisely.

How We Chose the Best St John’s Wort and Valerian Supplements

Our selection process is rigorous, combining data from Amazon, expert health insights, and customer feedback. We prioritized:

• High Amazon Ratings: Products with 4+ stars and 500+ reviews.
• Standardized Extracts: At least 0.3% hypericin for St John’s Wort and potent Valerian extracts.
• Certifications: GMP, Non-GMO, third-party tested, or organic.
• Price-to-Value Ratio: Balancing cost with quality and supply duration.
• Customer Feedback: Emphasis on effectiveness, tolerability, and ease of use.

We analyzed thousands of reviews and cross-referenced with health websites like WebMD and ConsumerLab to ensure authoritative recommendations.

Top 10 St John’s Wort and Valerian Supplements in 2025

1. Pascoe Neurapas Balance – Triple Herbal Mood Support

• Product Description: Pascoe Neurapas Balance is a premium supplement combining St John’s Wort, Valerian, and Passionflower for a holistic approach to mood and stress management. Crafted in Germany, this formula leverages a potent blend of 60 mg St John’s Wort (4.6-6.5:1 extract, standardized to 0.3% hypericin), 28 mg Valerian (3.8-5.6:1 extract), and 32 mg Passionflower to promote emotional balance and relaxation. Its non-habit-forming nature makes it suitable for long-term use, and the tablets are designed for easy swallowing. Ideal for those seeking a synergistic herbal blend backed by clinical research, Neurapas stands out for its quality and efficacy.

Buy It From Amazon

• Price: ~$29.99
• Key Features and Benefits:
  • Triple-herb formula for mood, stress, and sleep support.
  • Standardized extracts ensure consistent potency.
  • Non-GMO, with minimal fillers for clean supplementation.
  • Clinically studied for mood balance and tolerability.
• Pros:
  • Synergistic blend enhances efficacy over single-herb supplements.
  • Well-tolerated with minimal side effects reported.
  • Trusted brand with a history of herbal expertise.
• Cons:
  • Higher price point compared to single-herb options.
  • Contains lactose, unsuitable for lactose-intolerant individuals.
• Amazon Customer Ratings and Reviews: 4.5/5 stars (1,200+ reviews). Customers praise its mood-lifting and calming effects, often noting improvements within 2–3 weeks. Some report mild digestive upset initially.
• Why It’s a Good Choice: Its multi-herb formula offers comprehensive support for mood and stress, making it a top pick for those seeking a balanced, natural solution.
• Ideal Use Case: Adults managing mild depression, anxiety, or occasional sleep disturbances who prefer a premium, multi-ingredient supplement.

2. VEGATOT Organic Cortisol Wellness Complex

• Product Description: VEGATOT’s Organic Cortisol Wellness Complex is a powerhouse 15-in-1 formula, blending 450 mg St John’s Wort, Valerian, Ashwagandha, Rhodiola Rosea, Passionflower, Chamomile, and more to tackle stress, mood, and sleep issues. This vegan, Non-GMO, and gluten-free supplement is crafted in the USA under GMP standards, ensuring purity and potency. Each serving delivers a robust dose of adaptogens and calming herbs, making it a versatile choice for those seeking all-around wellness support. The 180-capsule bottle offers a 3-month supply, providing excellent value for a comprehensive formula.

Buy It From Amazon

• Price: ~$16.99
• Key Features and Benefits:
  • 15-in-1 blend for mood, stress, hormone balance, and sleep.
  • Organic and vegan-friendly, free of artificial additives.
  • High potency with 450 mg St John’s Wort per serving.
  • Supports energy, focus, and relaxation simultaneously.
• Pros:
  • Comprehensive formula addresses multiple wellness needs.
  • Cost-effective for a multi-ingredient supplement.
  • Highly rated for reducing stress and improving mood.
• Cons:
  • Large capsule size may be difficult for some to swallow.
  • Some users report mild digestive discomfort initially.
• Amazon Customer Ratings and Reviews: 4.6/5 stars (2,500+ reviews). Users rave about its all-in-one approach, with many reporting improved mood and sleep within weeks. A few mention a slow onset of effects.
• Why It’s a Good Choice: Perfect for those wanting a single supplement to address stress, mood, and energy holistically.
• Ideal Use Case: Busy professionals or parents needing daily stress relief and mood support.

3. Nature’s Bounty St John’s Wort with Valerian

• Product Description: Nature’s Bounty combines 300 mg St John’s Wort (standardized to 0.3% hypericin) with Valerian in a budget-friendly formula designed to promote a positive mood and tranquility. This Non-GMO supplement is free of artificial colors, flavors, and preservatives, making it a reliable choice from a well-known brand. The 100-capsule bottle is ideal for those new to herbal supplements, offering a gentle introduction to St John’s Wort and Valerian benefits. Its standardized extract ensures consistent potency, and the capsules are easy to incorporate into daily routines.

Buy It From Amazon

• Price: ~$15.39
• Key Features and Benefits:
  • Standardized to 0.3% hypericin for reliable mood support.
  • Affordable option from a trusted brand.
  • Supports emotional well-being and relaxation.
  • Free of common allergens like gluten and dairy.
• Pros:
  • Cost-effective for budget-conscious buyers.
  • Easy-to-swallow capsules with no aftertaste.
  • Effective for mild mood enhancement.
• Cons:
  • Lower potency compared to premium blends.
  • Limited sleep benefits for some users.
• Amazon Customer Ratings and Reviews: 4.4/5 stars (3,000+ reviews). Customers appreciate its affordability and mood support, though some note minimal impact on sleep.
• Why It’s a Good Choice: A great entry-level option for those exploring herbal mood support without breaking the bank.
• Ideal Use Case: Budget-conscious individuals seeking mild mood enhancement.

4. Gaia Herbs Emotional Balance

• Product Description: Gaia Herbs Emotional Balance is a vegan-friendly supplement featuring St John’s Wort, Valerian, Passionflower, Vervain, and Oats, sourced from Gaia’s organic farm. Each capsule delivers a potent dose of standardized St John’s Wort (0.3% hypericin) and Valerian to support stress resilience and emotional well-being. This 60-capsule bottle provides a 20-day supply, emphasizing quality over quantity. Its clean, plant-based formula is third-party tested for purity, making it a favorite among eco-conscious consumers seeking natural mood support.

Buy It From Amazon

• Price: ~$31.49
• Key Features and Benefits:
  • Certified organic and Non-GMO ingredients.
  • Includes synergistic herbs for enhanced calming effects.
  • Third-party tested for purity and potency.
  • Vegan and gluten-free for broad dietary compatibility.
• Pros:
  • High-quality, sustainably sourced ingredients.
  • Effective for stress and mood swings, including PMS.
  • Clean formula with minimal fillers.
• Cons:
  • Shorter supply per bottle increases long-term cost.
  • Premium price may deter some buyers.
• Amazon Customer Ratings and Reviews: 4.5/5 stars (1,800+ reviews). Users praise its mood-stabilizing effects, though some note the higher cost.
• Why It’s a Good Choice: Ideal for those prioritizing organic, sustainable supplements with proven efficacy.
• Ideal Use Case: Individuals with stress-related mood fluctuations or eco-conscious buyers.

5. Healths Harmony St John’s Wort & Valerian Blend

• Product Description: Healths Harmony delivers a potent blend of 500 mg St John’s Wort (standardized to 0.3% hypericin, 900 mcg per serving) and Valerian for mood and relaxation support. Manufactured in a GMP-certified facility, this Non-GMO, gluten-free supplement ensures high purity and bioavailability. The 120-capsule bottle offers a 4-month supply, making it a cost-effective choice for long-term use. Customers report significant reductions in anxiety and improved sleep quality, making it a strong contender for those seeking targeted relief.

Buy It From Amazon

• Price: ~$13.97
• Key Features and Benefits:
  • High-potency St John’s Wort with 900 mcg hypericin.
  • Supports anxiety relief and restful sleep.
  • Long-lasting supply for consistent use.
  • Free of artificial additives and allergens.
• Pros:
  • High hypericin content for maximum efficacy.
  • Affordable for the potency and supply duration.
  • Positive feedback on anxiety and sleep benefits.
• Cons:
  • May cause mild headaches if not taken with water.
  • Not suitable for severe depression without medical guidance.
• Amazon Customer Ratings and Reviews: 4.7/5 stars (2,200+ reviews). Users highlight significant anxiety relief and mood improvement, with some noting a 2–3 week onset.
• Why It’s a Good Choice: A strong choice for targeted anxiety and sleep support with high potency.
• Ideal Use Case: Individuals with mild anxiety or stress-related sleep issues.

6. NOW Supplements St John’s Wort with Valerian Root

• Product Description: NOW Supplements offers a balanced formula combining 300 mg St John’s Wort (standardized to 0.3% hypericin) and Valerian root extract to promote a calm, positive mood and restful sleep. This Non-GMO, kosher-certified supplement is manufactured in a GMP-certified facility, ensuring quality and safety. The 100-capsule bottle provides a cost-effective option for those seeking a reliable, no-frills herbal blend. Known for its consistent potency and clean ingredient profile, this product is a favorite among health-conscious consumers looking for natural mood and relaxation support.

Buy It From Amazon

• Price: ~$16.99
• Key Features and Benefits:
  • Standardized St John’s Wort extract for reliable mood support.
  • Includes Valerian root for enhanced calming effects.
  • Free of gluten, soy, and artificial additives.
  • Kosher and Non-GMO certifications ensure dietary inclusivity.
• Pros:
  • Affordable price for a trusted brand.
  • Easy-to-swallow capsules with no strong odor.
  • Effective for mild anxiety and mood support.
• Cons:
  • May require 3–4 weeks for noticeable effects.
  • Some users report mild drowsiness during the day.
• Amazon Customer Ratings and Reviews: 4.3/5 stars (2,800+ reviews). Customers appreciate its affordability and mood benefits, though some note slower onset compared to higher-potency options.
• Why It’s a Good Choice: A solid, budget-friendly choice for those seeking a straightforward St John’s Wort and Valerian blend from a reputable brand.
• Ideal Use Case: Individuals new to herbal supplements or those managing mild mood issues on a budget.

7. duwhot St John’s Wort & Valerian Gummies

• Product Description: duwhot’s St John’s Wort & Valerian Gummies offer a tasty, convenient alternative to capsules, delivering 250 mg St John’s Wort and Valerian extract per serving in a natural berry flavor. These vegan, gluten-free gummies are formulated to support mood balance and relaxation without the need to swallow pills. Made with organic ingredients and free of artificial sweeteners, this 60-gummy bottle provides a 30-day supply. Perfect for those who dislike capsules or want a portable, enjoyable supplement option, duwhot’s gummies combine efficacy with ease of use.

Buy It From Amazon

• Price: ~$18.89
• Key Features and Benefits:
  • Chewable gummies for easy consumption.
  • Vegan, gluten-free, and organic ingredients.
  • Supports mood stability and stress relief.
  • Pleasant berry flavor enhances compliance.
• Pros:
  • Convenient for those who dislike pills.
  • High-quality, clean ingredient profile.
  • Effective for mild stress and mood support.
• Cons:
  • Lower potency compared to capsule-based options.
  • Contains natural sugars, not ideal for low-sugar diets.
• Amazon Customer Ratings and Reviews: 4.4/5 stars (1,500+ reviews). Users love the taste and convenience, though some wish for higher potency for stronger effects.
• Why It’s a Good Choice: Ideal for those seeking a user-friendly, tasty supplement for mild mood and stress support.
• Ideal Use Case: Younger adults or those who prefer gummies over capsules for daily wellness.

8. VVN Naturals Calm Mood Gummies

• Product Description: VVN Naturals Calm Mood Gummies combine St John’s Wort, Valerian, Lemon Balm, and Passionflower in a delicious mango-flavored gummy. Each serving delivers 200 mg St John’s Wort and Valerian alongside synergistic herbs to promote relaxation and emotional balance. These vegan, Non-GMO gummies are third-party tested for purity and potency, ensuring a high-quality product. The 60-gummy bottle offers a 30-day supply, making it a convenient choice for those seeking a flavorful, plant-based supplement to manage stress and mood fluctuations.

Buy It From Amazon

• Price: ~$20.99
• Key Features and Benefits:
  • Multi-herb formula for enhanced calming effects.
  • Vegan, Non-GMO, and third-party tested.
  • Mango flavor improves daily compliance.
  • Supports stress relief and restful sleep.
• Pros:
  • Tasty and easy to incorporate into routines.
  • Synergistic herbs boost efficacy.
  • Clean, high-quality ingredients.
• Cons:
  • Slightly higher price for gummies.
  • Lower St John’s Wort potency per serving.
• Amazon Customer Ratings and Reviews: 4.5/5 stars (1,300+ reviews). Customers praise the flavor and calming effects, though some note mild effects for severe anxiety.
• Why It’s a Good Choice: A great option for those who want a tasty, multi-herb gummy for stress and mood support.
• Ideal Use Case: Individuals with mild stress or sleep issues who prefer flavorful supplements.

9. Pure Mountain Botanicals St John’s Wort & Valerian Capsules

• Product Description: Pure Mountain Botanicals offers a high-potency blend of 450 mg St John’s Wort (0.3% hypericin) and Valerian root extract in vegan capsules. Sourced from organic herbs, this supplement is designed to support mood stability and relaxation. The 90-capsule bottle provides a 45-day supply, and its Non-GMO, gluten-free formula is third-party tested for purity. With a focus on clean, sustainable ingredients, this product is ideal for those seeking a premium, eco-friendly supplement for emotional wellness and stress relief.

Buy It From Amazon

• Price: ~$16.58
• Key Features and Benefits:
  • Organic, high-potency St John’s Wort and Valerian.
  • Vegan capsules with no artificial fillers.
  • Third-party tested for quality assurance.
  • Supports mood balance and restful sleep.
• Pros:
  • High potency for effective mood support.
  • Sustainable, organic ingredients.
  • Well-tolerated with minimal side effects.
• Cons:
  • Premium price may not suit all budgets.
  • Some users report a mild herbal aftertaste.
• Amazon Customer Ratings and Reviews: 4.6/5 stars (1,600+ reviews). Customers highlight its effectiveness for mood and sleep, though some note a gradual onset.
• Why It’s a Good Choice: Perfect for eco-conscious buyers seeking a potent, organic supplement.
• Ideal Use Case: Those with moderate stress or mood issues prioritizing organic products.

10. Horbäach St John’s Wort & Valerian Tincture

• Product Description: Horbäach’s St John’s Wort & Valerian Tincture offers a liquid alternative for rapid absorption, delivering 2,000 mg equivalent of St John’s Wort and Valerian per serving. This alcohol-free tincture is ideal for those who prefer sublingual administration or have difficulty swallowing pills. Formulated with Non-GMO ingredients and lab-tested for purity, this 2 oz bottle provides a 30-day supply. Its potent formula supports mood balance, anxiety relief, and restful sleep, making it a versatile choice for natural wellness enthusiasts.

Buy It From Amazon

• Price: ~$8.99
• Key Features and Benefits:
  • High-potency liquid extract for fast absorption.
  • Alcohol-free and Non-GMO.
  • Supports mood, anxiety, and sleep health.
  • Convenient dropper for customizable dosing.
• Pros:
  • Affordable and potent liquid formula.
  • Rapid absorption for quicker effects.
  • Easy to adjust dosage as needed.
• Cons:
  • Strong herbal taste may not suit everyone.
  • Requires careful storage to maintain potency.
• Amazon Customer Ratings and Reviews: 4.4/5 stars (1,400+ reviews). Users appreciate the fast-acting formula, though some dislike the taste.
• Why It’s a Good Choice: Ideal for those seeking a budget-friendly, fast-absorbing liquid supplement.
• Ideal Use Case: Individuals with mild to moderate anxiety or sleep issues who prefer tinctures.

Comparison Table

Note: Prices and ratings based on Amazon data as of August 2025. Check Amazon for the latest information.

Buying Guide: How to Choose the Right St John’s Wort and Valerian Supplement

• Potency: Opt for standardized St John’s Wort (0.3% hypericin) and potent Valerian extracts for consistent effects.
• Form: Choose capsules for high potency, gummies for convenience, or tinctures for rapid absorption.
• Certifications: Look for Non-GMO, organic, or third-party tested products to ensure quality.
• Additional Ingredients: Synergistic herbs like Passionflower or Ashwagandha can enhance benefits.
• Price vs. Value: Balance cost with potency and supply duration for the best value.
• Who Should Avoid: Pregnant women, those on SSRIs, or individuals with liver issues should consult a doctor.

Potential Side Effects and Precautions

• St John’s Wort: May cause photosensitivity or interact with medications like antidepressants, birth control, or blood thinners. Avoid combining with SSRIs to prevent serotonin syndrome.
• Valerian: Can cause drowsiness, dizziness, or mild headaches. Long-term use may lead to withdrawal symptoms.
• Recommendation: Start with a low dose, monitor effects, and consult a healthcare provider, especially if on other medications.

FAQs

• What is the best time to take St John’s Wort and Valerian?
  St John’s Wort is typically taken in the morning or afternoon to avoid sleep disruption, while Valerian is best at night for sleep support.
• Can I take these supplements together?
  Yes, they’re often combined for synergistic effects, but consult a doctor to avoid interactions.
• How long does it take to see results?
  Effects may take 2–4 weeks for mood support and 1–2 weeks for sleep benefits.
• Are these supplements safe for long-term use?
  Generally safe for short-term use; long-term safety requires medical supervision.

Conclusion

The best 10 St John’s Wort and Valerian supplements of 2025 offer diverse options for mood, stress, and sleep support, from budget-friendly capsules like Nature’s Bounty to premium organic blends like Gaia Herbs. Whether you prefer gummies, tinctures, or high-potency capsules, our detailed reviews and comparison table help you find the perfect fit. Always consult a healthcare provider to ensure safety, especially if you’re on medications. Choose your ideal supplement today and start your journey to natural emotional wellness!